ISSN 1119-4618
 

Original Research 


SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES

Ogunkemi Risikat Agbeke Iyun, Kasali A Bello, Ovie J Abayeh, Aliyu Jauro, Grace Yakariok Kantiok.

Abstract
A group of 5 N-Substituted-3-cyano-4-methyl-6-hydroxy-2-pyridones were synthesised with focus on changing the substituents on the nitrogen atom of the pyridone ring. The melting point range of the pyridones was 205-298oC. All products obtained from the synthesis were coloured white and the percentage yield determined was 60,30,95.8,63.7,66.6% for 3-cyano-6-hydroxy-4-methyl-2-pyridone,3-cyano-6-hydroxy-1,4-dimethyl-2-pyridone,3-cyano-1-ethyl-6-hydroxy-4-methyl-2-pyridone,1-butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone,3-cyano-6-hydroxy-1-methoxypropyl-4-methyl-2-pyridone respectively. The IR spectra of the products showed OH stretch at around 2900cm-1, carbonyl stretch at about 1600cm-1 and also CN stretch at about 2200cm-1. Ar-H peaks were observed at about 5ppm due to the single hydrogen on the pyridone ring at position 5, also at about 2.09-2.51ppm peaks methyl protons where observed.

Key words: Pyridone,Synthesis,N-Substitued


 
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How to Cite this Article
Pubmed Style

Iyun ORA, Bello KA, Abayeh OJ, Jauro A, Kantiok GY, . SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES . JPAS. 2019; 17(1): 49-53. doi:10.5455/sf.21578


Web Style

Iyun ORA, Bello KA, Abayeh OJ, Jauro A, Kantiok GY, . SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES . http://www.atbuscienceforum.com/?mno=21578 [Access: February 24, 2020]. doi:10.5455/sf.21578


AMA (American Medical Association) Style

Iyun ORA, Bello KA, Abayeh OJ, Jauro A, Kantiok GY, . SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES . JPAS. 2019; 17(1): 49-53. doi:10.5455/sf.21578



Vancouver/ICMJE Style

Iyun ORA, Bello KA, Abayeh OJ, Jauro A, Kantiok GY, . SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES . JPAS. (2019), [cited February 24, 2020]; 17(1): 49-53. doi:10.5455/sf.21578



Harvard Style

Iyun, O. R. A., Bello, K. A., Abayeh, O. J., Jauro, A. ., Kantiok, G. Y. & (2019) SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES . JPAS, 17 (1), 49-53. doi:10.5455/sf.21578



Turabian Style

Iyun, Ogunkemi Risikat Agbeke, Kasali A Bello, Ovie J Abayeh, Aliyu Jauro, Grace Yakariok Kantiok, and . 2019. SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES . Science Forum (Journal of Pure and Applied Sciences), 17 (1), 49-53. doi:10.5455/sf.21578



Chicago Style

Iyun, Ogunkemi Risikat Agbeke, Kasali A Bello, Ovie J Abayeh, Aliyu Jauro, Grace Yakariok Kantiok, and . "SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES ." Science Forum (Journal of Pure and Applied Sciences) 17 (2019), 49-53. doi:10.5455/sf.21578



MLA (The Modern Language Association) Style

Iyun, Ogunkemi Risikat Agbeke, Kasali A Bello, Ovie J Abayeh, Aliyu Jauro, Grace Yakariok Kantiok, and . "SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES ." Science Forum (Journal of Pure and Applied Sciences) 17.1 (2019), 49-53. Print. doi:10.5455/sf.21578



APA (American Psychological Association) Style

Iyun, O. R. A., Bello, K. A., Abayeh, O. J., Jauro, A. ., Kantiok, G. Y. & (2019) SYNTHESIS AND CHARACTERIZATION OF N-SUBSTITUTED-3-CYANO-6- HYDROXY-4-METHYL-2-PYRIDONES . Science Forum (Journal of Pure and Applied Sciences), 17 (1), 49-53. doi:10.5455/sf.21578